| ID |
http://id.who.int/icd/entity/63677983 |
| Preferred Name |
trouble du mouvement auto-immunitaire, auto-anticorps positif |
| Definitions |
Autoimmune movement disorder seropositive for neural autoantibodies. When these neural antibodies target plasma membrane antigens they are effectors of injury (e.g. N-methyl-D-aspartate receptor antibodies) through multiple effector mechanisms. However, when targeting nuclear or cytoplasmic antigens (e.g. voltage gated-potassium channel complex autoantibodies) they are markers of a T-cell effector mediated injury as they are inaccessible to immune attack in situ, but peptides from intracellular proteins are displayed on upregulated MHC class 1 molecules in a pro-inflammatory cytokine milieu and then accessible to peptide specific cytotoxic T-cells. Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase-like protein-6); GAD65 (glutamic acid decarboxylase-65 antibodies); NMDA-R (N-methyl-D-aspartate receptor autoantibodies); VGKC ( voltage gated calcium channel LGI1, CASPR2) |
| Type |
http://www.w3.org/2002/07/owl#Class |
| comment | Autoimmunbewegungsstörung seropositiv für neuronale Autoantikörper. Wenn diese neuralen Antikörper auf Plasmamembran-Antigene zielen, sind sie Effektoren der Verletzung (z.B. n-Methyl-d-Aspartat-Rezeptor-Antikörper) durch multiple Effektor-Mechanismen. Wenn sie jedoch auf nukleare oder zytoplasmatische Antigene zielen (z.B. voltage gated-kalium channel complex autoantikörper), sind sie Marker einer T-Zell-Effektor-vermittelten Verletzung, da sie für Immunangriffe in situ unzugänglich sind. assoziierte neurale Autoantikörper umfassen: dppx (dipeptidyl-peptidase-ähnliches Protein-6), gad65 (glutamic acid decarboxy lorsque ces anticorps neuronaux ciblent les antigènes de la membrane plasmique, ils effectent la lésion (p. ex. anticorps des récepteurs n-méthyl-d-aspartate) par de multiples mécanismes effecteurs. cependant, lorsqu'on cible des antigènes nucléaires ou cytoplasmiques (p. ex., autoanticorps du complexe du canal potassium-voltage protégés), ils sont des marqueurs d'une lésion médiée par un effecteur de lymphocytes t parce qu'ils sont inaccessibles à une attaque immunitaire in situ, mais les peptides des protéines intracellulaires sont affichés sur des molécules de classe 1 du mhc régulé dans un milieu cytokine pro-inflammatoire et ensuite accessibles aux lymphocytes t cytotoxiques spécifiques des peptides. les autoanticorps neuronaux associés comprennent : dppx (protéine semblable à la dipeptidyl-peptidase-6), gad65 (anticorps de décarboxylase acide glutamique autoimmune ruchu nieładu seropositive dla neural autoantibodies.when te neural niwecznik celować osocze osocze niweczniki są efektory kontuzja (e.g. n-methyl-d-aspartate receptor przeciwciała) przez wieloskładnikowych efekt. jakkolwiek targetuje jądrowych lub cytoplasmic niweczniki, (dipeptidyl-peptidase-like protein-6), gad65 (glutamic acid decarboxylase-65 antibodies), nmda-r (n-metyl-d-aspartate receptor autoantibodies), nmda-r (n-metyl-d-aspartate receptor autoantibodies), gad65 (glutamic kwas decarboxylase-65 niweczniki), nmda-r (n-metyl-d-aspartate Autoimmune movement disorder seropositive for neural autoantibodies. When these neural antibodies target plasma membrane antigens they are effectors of injury (e.g. N-methyl-D-aspartate receptor antibodies) through multiple effector mechanisms. However, when targeting nuclear or cytoplasmic antigens (e.g. voltage gated-potassium channel complex autoantibodies) they are markers of a T-cell effector mediated injury as they are inaccessible to immune attack in situ, but peptides from intracellular proteins are displayed on upregulated MHC class 1 molecules in a pro-inflammatory cytokine milieu and then accessible to peptide specific cytotoxic T-cells. Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase-like protein-6); GAD65 (glutamic acid decarboxylase-65 antibodies); NMDA-R (N-methyl-D-aspartate receptor autoantibodies); VGKC ( voltage gated calcium channel LGI1, CASPR2) αυτοάνοση κίνηση διαταραχή seropositive for neural autoantibodies.when these neural antibodies target plasma membrane antigens they are effectors of injury (π.χ. n-methyl-d-aspartate receptor antibodies), nmda-r (n-methyl-d-aspartate receptor antibodies), nmda-r (n-methyl-d-aspartate receptor antibodies), nmda-r (n-methyl-d-aspartate receptor antibodies), τα gadtides των ενδοκυτταρικών πρωτεϊνών εμφανίζονται πάνω σε ανεξέλεγκτα μόρια mhc 1), σε ένα προ-φλεγμονώδες κυτοκίνη και κατόπιν προσιτό στο πεπτίδιο ειδικών κυτταρολογικών t-cells. συναφών νευρολογικών αυτοαντισωμάτων περιλαμβάνουν: dppx (dipeptidyl-peptidase-like protein |
| broaderTransitive | |
| prefLabel | trouble du mouvement auto-immunitaire, auto-anticorps positif |
| browserUrl | NA |
| label | autoimmunologicznych zaburzenia ruchu, autoantibody pozytywne trouble du mouvement auto-immunitaire, auto-anticorps positif αυτοάνοση διαταραχή κίνησης, αυτοαντισώματα θετική Autoimmunkrankheit, Autoantikörper positiv Autoimmune movement disorder, autoantibody positive |
| subClassOf |
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